Radiation Oncology Journal
- 제14권3호
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- Pages.221-228
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- 1996
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
난소 미분화세포종의 치료 결과
Treatment Results of Ovarian Dysgerminoma
- 정은지 (연세대학교 의과대학 치료방사선과학교실, 연세암센터) ;
- 서창옥 (연세대학교 의과대학 치료방사선과학교실, 연세암센터) ;
- 성진실 (연세대학교 의과대학 치료방사선과학교실, 연세암센터) ;
- 금기창 (연세대학교 의과대학 치료방사선과학교실, 연세암센터) ;
- 김귀언 (연세대학교 의과대학 치료방사선과학교실, 연세암센터)
- Chung, Eun-Ji (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University) ;
- Suh, Chang-Ok (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University) ;
- Seong, Jin-Sil (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University) ;
- Keum, Ki-Chang (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University) ;
- Kim, Gwi-Eon (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University)
- 발행 : 1996.09.01
초록
목적 : 난소 미분화세포종의 임상적 특징과 치료 방법, 국소 제어율, 치료 실패 양상, 생존율 등 치료 성적을 분석해 보고, 가임력을 보존하기 원하는 병기 13 환자들에서의 적절한 치료 방침을 찾아보고자 본 연구를 시행하였다. 대상 및 방법 : 1975년 1월부터 1990년 12월까지 연세 의대 신촌 세브란스병원, 연세암센터에서 진단 및 치료를 받은 34명의 난소 미분화세포종 환자를 대상으로 하였다. 이중 2예의 gonadoblastoma(46,XY)와 3예의 혼합 배세포종(mixed germ cell tumor)을 제외하고 나머지 순수 미분화세포종(pure dysgermlnoma) 환자 29예만을 연구 대상으로 하여 치료 방법에 따라 두군으로 나누어 성적을 분석하였다. 1군은 수술후 보조적 방사선치료를 받은 환자로 21예였고, 2군은 수술후 보조적 방사선치료를 하지 않은 군으로 8예였다. 대상 환자의 연령 분포는 8-39세였고 중앙치는 23세였다. 진단 시 임상 증상은 촉지되는 복부 골반부 종괴가 가장 호발하였다. 병기는 I이 23명으로
Purpose : We tried to evaluate the clinical characteristics, the treatment methods, the results of treatments, and the Patterns of failure in ovarian dysgerminoma retrospectively According to the results we would like to suggest the proper management guideline of stage la ovarian dysgerminoma patients who want to maintain fertility. Materials and Methods : Between 1975 and 1990, 34 patients with ovarian dysgerminoma were treated at the Yonsei University Hospital. The case records of these patients have been reviewed for presenting symptoms, treatment methods, local control and survival following treatment. Excluded from analysis were five patients with mixed ovarian germ cell tumors and gonadoblastomas (46,XY) Treatment results of the twenty nine patients were analysed by each treatment modality. Twenty one patients were treated with surgery and postoperative adjuvant radiotherapy (group 2). The other eight patients were treated with operation alone (group 2). The median age of twenty-nine patients was 23 years with a range of 8 to 39 years. Presenting symptoms were abdominal mass (20) pelvic discomfort or pain (5) et al. Radiotherapy was performed by 10MV LINAC or Co-60 teletherapy unit. The total radiation dose of the whole abdomen was 20-25 Gy/3weeks, 1-1.5 Gy/fraction with a boost to the whole pelvis 10-15 Gy/l-2weeks 1.8-2.0 Gy/fraction. Advanced stage disease (stage II or stage III) patients received prophylactic mediastinal and supraclavicular irradiation to a dose of 16-26 Gy. Median duration of follow-up of living patients was 80 months (range 13-201 months). Results : All of the twenty one patients of group 1 were alive without disease (