대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

관동화전탕액(款冬花煎湯液)이 기관지평골근(氣管支平滑筋)에 미치는 영향(影響)

FARFARAE FLOS INHIBITS HISTAMINE-INDUCED CONTRACTILE RESPONSES OF AIRWAY SMOOTH MUSCLE

  • 한종현 (원광대학교 한의과대학 약리학교실,원광대학교 의약자료연구센터) ;
  • 강성용 (원광대학교 한의과대학 약리학교실,원광대학교 의약자료연구센터) ;
  • 유광석 (원광대학교 한의과대학 약리학교실,원광대학교 의약자료연구센터) ;
  • 진상식 (원광대학교 한의과대학 약리학교실,원광대학교 의약자료연구센터) ;
  • 하경화 (원광대학교 한의과대학 약리학교실,원광대학교 의약자료연구센터) ;
  • 이경자 (원광대학교 한의과대학 약리학교실,원광대학교 의약자료연구센터)
  • Han, Jong-Hyun (College of Oriental Medicine, Wonkwang University,Medicinal Resources Research Center of Wonkwang University) ;
  • Kang, Sung-Yong (College of Oriental Medicine, Wonkwang University,Medicinal Resources Research Center of Wonkwang University) ;
  • Yu, Kwang-Suk (College of Oriental Medicine, Wonkwang University,Medicinal Resources Research Center of Wonkwang University) ;
  • Jin, Sang-Sik (College of Oriental Medicine, Wonkwang University,Medicinal Resources Research Center of Wonkwang University) ;
  • Ha, Kyung-Hwa (College of Oriental Medicine, Wonkwang University,Medicinal Resources Research Center of Wonkwang University) ;
  • Lee, Kyung-Ja (College of Oriental Medicine, Wonkwang University,Medicinal Resources Research Center of Wonkwang University)
  • 발행 : 1996.03.30
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초록

Farfarae Flos, a traditional herb medicine, has been used in Korea and China for many centuries as a treatment for respiratory disease. The purpose of the present study was to determine the effect of Farfarae Flos on histamine-induced tracheal smooth muscle contraction in rats. Guinea pigs(500g, female) were killed by CO2 exposure and a segment (8-10mm) of the thoracic trachea from each guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine which evoked 50% of maximal response (ED50) was obtained from cumulative dose response curves for histamine (10-7-10-4M). Contractions evoked by histamine(ED50) were inhibited significantly by Farfarae Flos. The mean percent inhibition was 8.7% after 1.5mg/ml Farfarae Flos, and 33.5% (p<0.05) after 5.0mg/ml Farfarae Flos. Propranolol (10-7M) slightly but significantly attenuated the inhibitory effects of Farfarae Flos. Following treatment with propranolol, the mean percent inhibition caused by 5.0mg/ml Farfarae Flos. Indomethacin and methylene blue (10-7M) did not significantly alter the inhibitory effect of Farfarae Flos. These results indicate that Farfarae Flos can relax histamine-induced contraction of guinea pig tracheal smooth muscle, and that this inhibition involves, in part, symphathetic nerve system.

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