생약학회지 (Korean Journal of Pharmacognosy)
- 제27권4호
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- Pages.295-300
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- 1996
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
인삼노두 추출물의 위염 및 위궤양에 대한 효과
Antigastritic and Antiulcer Actions of the Extract of Head of Panax ginseng Radix
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Jung, Ki-Hwa
(College of Pharmacy, Duksung Women's University) ;
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Lee, Eun-Bang
(Natural Products Research Insitute, Seoul National University) ;
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Chung, Chun-Sik
(College of Pharmacy, Duksung Women's University)
- 발행 : 1996.12.30
초록
In a preliminary screening of plant extracts for the antigastritic and antiulcer actions in rats, the extracts of head of Panax ginseng Radix showed positive activity in HCl ethanol-induced gastric lesion. Among the systematic fractions of hexane, chloroform, butanol and water, the most potent butanol fraction reduced significantly HCl ethanol-induced gastric lesion at the oral dose of 500 mg/kg. In pylorus ligated rats, hexane and butanol fraction showed decreases in the volume of gastric secretion and acid output, of which effects were stronger in butanol fraction. Further assays with butanol fraction disclosed that it significantly suppressed the aspirin-induced and Shay ulcer. The butanol fraction at the intraduodenal dose of 500 mg/kg showed significant stimulation of mucus secretion.