생약학회지 (Korean Journal of Pharmacognosy)
- 제27권4호
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- Pages.350-353
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- 1996
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
인삼 비당부와 땅빈대의 뇌암세포 독성작용
Cytotoxic Activities of Panax ginseng and Euphorbia humifusa in Human Brain Tumor Cells
- Cha, Bae-Cheon (Department of Animal Nutrition & Resources, Sangji University) ;
- Kim, Jung-Ae (Department of Molecular Biology, Pusan National University) ;
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Lee, Yong-Soo
(Department of Physiology, College of Medicine, Kwandong University)
- 발행 : 1996.12.30
초록
The effects of acid hydrolysis product of Panax ginseng and MeOH extract of Euphorbia humifusa on the growth of human brain tumor cells were evaluated using U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cells as model cellular systems. These plant extracts induced cytotoxicity in both cells in a dose-dependent manner. These cytotoxic effects were significantly inhibited by GSH, an antioxidant, in both cells. BAPTA/AM, an intracellular