Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Immunostimulating Components from the Root of Angelica gigas Nakai

참당귀(Angelica gigas Nakai) 뿌리의 면역증강활성 성분

  • Ahn, Kyung-Seop (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Sim, Woong-Seop (Department of Biology, Korea University) ;
  • Kim, Hwan-Mook (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Han, Sang-Bae (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Ik-Hwan (Korea Research Institute of Bioscience and Biotechnology, KIST)
  • Published : 1996.09.30
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Abstract

A potent immuno-stimulating activity was detected from the watersoluble and ethanol-precipitated crude extract (AG-1) of the root of Angelica gigas Nakai. The crude extract was fractionated into two fractions, an acidic AG-2 and a neutral AG-3 fraction by DEAE-cellulose adsorption. The two fractions contained polysaccharides of which M.W. were 10 Kdal and >2,000 Kdal respectively, proteins, and various inorganic components. The immunostimulating activities of two fractions were not reduced by proteinase K, acid or alkali treatment. The polysaccharides obtained from the root of A. gigas were mainly composed of arabinose, galactose, and galacturonic acid. These results indicated that immuno- stimulating components of the root of A. gigas was a kind of pectic polysaccharides or arabinogalactans.

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