Analytical Science and Technology (분석과학)

The Korean Society of Analytical Sciences (한국분석과학회)
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Determination of 2-Mercapto-1-methyl-imidazole in Antithyroid Drug by Differential Pulse Polarography

항갑상선 의약물 중 2-mercapto-1-methyl-imidazole의 펄스차이 폴라로그래피에 의한 분석

  • Kim, Il Kwang (Dept. of Chemistry, Call. of Natural Science, Wonkwang University) ;
  • Chun, Hyun Ja (Dept. of Chemistry, Call. of Natural Science, Wonkwang University) ;
  • Lim, Soon Hwa (Dept. of Chemistry, Call. of Natural Science, Wonkwang University)
  • 김일광 (원광대학교 자연과학대학 화학과) ;
  • 천현자 (원광대학교 자연과학대학 화학과) ;
  • 임순화 (원광대학교 자연과학대학 화학과)
  • Received : 1994.11.25
  • Published : 1995.03.25
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Abstract

The determination method of 2-mercapto-1-methyl-imidazole(MMI) in $5.0{\times}10^{-2}M$ lithium perchlorate solution has been investigated by the differential pulse polarography. The optimum conditions for the determination of MMI were as fellows; -0.9 volt(vs. Ag/AgCl) initial potential, 80mV pulse height, 2mV/sec scan rate, and medium mercury drop size. The calibration curve showed a good linearlity in the range of $1.0{\times}10^{-7}M$ to $8.0{\times}10^{-5}M$ and the detection limit was $2.2{\times}10^{-9}M$. This method was applicable to the determination of MMI in thyroid drugs without interference from the additives.

$5.0{\times}10^{-2}M$ $LiClO_4$ 용액 중에서 펄스차이 폴라그래피로 2-mercapto-1-methyl-imidazole(MMI)의 정량방법을 조사하였다. 분석의 최적 조건은 초기전위 -0.9 volt vs. Ag/AgCl, 펄스높이 80mV, 주사속도 2mV/sec, 중간 크기 수은방울이었다. 검정곡선은 $1.0{\times}10^{-7}M$에서 $8.0{\times}10^{-5}M$ 범위까지 좋은 직선성을 보여 주었으며, 검출한계는 $2.2{\times}10^{-9}M$이었다. 이 방법은 다른 첨가제의 방해 없이 항갑상선 치료제 중의 MMI 정량에 응용할 수 있었다.

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Acknowledgement

Supported by : 한국과학재단