The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Evaluation of Therapeutic Effect with Serum Thyroglobulin and Whole Body Scan after 200mCi $^{131}I$ Treatment in Patients with Well-Differentiated Thyroid Carcinoma

전이성 분화 갑상선암에서 200mCi 방사성 옥소 치료효과 평가를 위한 혈청 Thyroglobulin 추적검사와 전신스캔의 의의

  • Lee, Chang-Hee (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Yoon, Jong-Kil (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Jeong, Sang-Hoon (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Kwu, Gyo-Seon (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Choi, Chang-Woon (Department of Nuclear Medicine, Korea Cancer Center Hospital) ;
  • Lim, Sang-Moo (Department of Nuclear Medicine, Korea Cancer Center Hospital) ;
  • Hong, Sung-Woon (Department of Nuclear Medicine, Korea Cancer Center Hospital)
  • Published : 1995.12.25
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Abstract

Thirty-eight patients with metastatic well-differentiated thyroid carcinoma treated with 200mCi $^{131}I$ were studied. There were false negative serum thyroglobulin values during TSH suppression or at anti-thyroglobulin antibody(+) and discrepancies between findings of whole body scan and serum thyroglobulin level. After one to five cycles of 200mCi $^{131}I$ therapy, complete remission and partial remission were achieved at 5.3% and 57.9%, respectively. We concluded that all of serum thyroglobulin, TSH, anti-thyroglobulin antibody, $^{131}I$ or $^{123}I$ whole body scan were necessary in follow up of metastatic well-differentiated thyroid carcinoma. Also, if there was no response after repetitive 200mCi $^{131}I$ therapy, higher doses of $^{131}I$ therapy should be considered.

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