Textile Coloration and Finishing (한국염색가공학회지)

The Korean Society of Dyers and Finishers (한국염색가공학회)
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Development and Application of Biocompatible Polymers(II) ―Biocompatibility of Chitosan Graft Copolymer with Phosphoryl Choline groups―

생체적합성 고분자의 개발과 응용(II) ―Phosphoryl choline기를 가진 키토산 그래프트공중합체의 생체적합성―

  • Lee, Mi Kyung (Dept. of Textile Eng., College of Eng., Pusan National Univ., Pusan, Korea) ;
  • Park, Heung Sup (Dept. of Textile Eng., College of Eng., Pusan National Univ., Pusan, Korea) ;
  • Kim, Eun Young (Chang Shin Textile Co. Ltd) ;
  • Park, Soo Min (Dept. of Textile Eng., College of Eng., Pusan National Univ., Pusan, Korea)
  • Published : 1995.06.01
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Abstract

To improve the blood compatibility of chitosan membranes, 2-(methacryloyloxy)-ethyl-2-(trimethylammonium)ethyl phosphate(MTP), which is a methacrylate with phospholipid polar groups, was grafted on the surface of chitosan membranes and the biocompatibility of MTP-grafted chitosan membranes was investigated. The permeation coefficient gradually decreased with increasing in molecular weights of biocomponents below 10$^{4}$, and drastically decreased above 10$^{4}$. This result corresponds with the permeability of solutes in case of hemodialysis membranes. The MTP-grafted chitosan membranes displayed less blood cell adhesion than the chitosan membranes. This may due to the formation of biomembrane4ike surface by adsorption and arrangement of phospholipid molecules from serum onto the MTP copolymer surface.

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