한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제23권2호
  • /
  • Pages.123-130
  • /
  • 1995
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

DNA topoisomerase I Inhibitor 를 생성하는 방선균 분리균주의 수리동정

Numerical Identification of an Actinomycetes Strain Producing an Antitumor Antibiotic with Inhibitory Activity against DNA Topoisomerase

  • 이동선 (경북대학교 미생물학과) ;
  • 하상철 (한국과학기술연구원 부설 유전공학연구소) ;
  • 신우창 (경북대학교 미생물학과) ;
  • 김태호 (경북대학교 미생물학과) ;
  • 김홍중 (한국과학기술연구원 부설 유전공학연구소) ;
  • 박용하 (한국과학기술연구원 부설 유전공학연구소) ;
  • 김종국 (경북대학교 미생물학과) ;
  • 홍순덕 (경북대학교 미생물학과)
  • 발행 : 1995.05.01
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초록

DNA topoisomerase I have been shown to be important therapeutic target in cancer chemotherapy. Chemotaxonomy and numerical identification were carried out for an isolate strain No.7489 producing an antibiotic that inhibits DNA topoisomerase I activity. The genus of strain No.7489 was determined as Streptomyces sp. from culture, morphological and chemotaxonomic data. Thirty-nine taxonomic unit characters were tested and the data were analyzed numerically using the TAXON program. The isolate was best matched to Streptomyces melanosporofaciens in the major cluster 32 of Streptomyces. Therefore, it was concluded that the isolate was identified to be a member of Streptomyces melanosporofaciens.

키워드

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