한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제23권5호
  • /
  • Pages.526-530
  • /
  • 1995
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Umbilicaria esculenta가 생산하는 Depside계 화합물의 구조 및 Phospholipase $A_2$ 저해활성

A Phospholipase $A_2$ Inhibitor Isolated from Umilicaria esculenta

  • 김진우 (한국과학기술연구원 생명공학연구소) ;
  • 송경식 (경북대학교 농화학과) ;
  • 장현욱 (영남대학교 약학대학) ;
  • 유승헌 (충남대학교 농생물학과) ;
  • 유익동 (한국과학기술연구원 생명공학연구소)
  • 발행 : 1995.10.01
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초록

Phospholipase A$_{2}$ (PLA$_{2}$) is lipolytic enzyme that has known to be involved in inflammation. In the course of our screening for antiinflammatory compounds from natural products, a compound having PLA$_{2}$ inhibitory activities was isolated from the methanol extract of Umbilicaria esculenta. The compound was identified as lecanoric acid based on various NMR studies including DEPT, HETERO-COSY and HMBC experiments. Lecanoric acid inhibited human rheumatoid synovial PLA$_{2}$ activity with IC$_{50}$ of 0.17 mM and also exhibited antitumor activity (ED$_{50}$=2.7 $\mu $g/ml) against skin tumor cell line (LOX-IMVI).

키워드

참고문헌

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