Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Development of Antitoxic Agents from Korean Medicinal Plants. Part 4. Effects of Panax ginseng C. A. Meyer Extract on the Accumulation of Cadmium in Liver

한국산 생약으로 부터 해독물질의 개발(제4보) 흰쥐 간장내의 카드뮴 축적에 미치는 인삼 추출물의 영향

  • 백승화 (원광대학교 자연과학대학 화학과) ;
  • 유일수 (이리농공전문대학 화공과) ;
  • 이종섭 (원광대학교 의과대학 예방의학교실) ;
  • 한두석 (원광대학교 치과대학 구강해부학교실)
  • Published : 1995.12.01
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Abstract

This study was conducted to investigate the metallothionein (MT) induction by Panax ginseng C. A. Meyer in cadmium chloride intoxication. The results were as follows: Generally, detoxicatlon effects by Panax ginseng C. A. Meyer extract increased proportionally to the increase of cadmium concentrations. When a 8 mg/g dosage of cadmium was administered, formation of the cadmium and EDTA complex showed the highest antitoxic effect. Also, when a 4 mg/g dosage of cadmium was administered, Panax ginseng C. A. Meyer extract showed the highest antitoxic effect in metallothionein induction. According to the above results, Panax ginseng C. A. Meyer extract administered with cadmium increased metallothionein concentration and decreased the toxicity of cadmium in liver.

Keywords

References

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