Relationship between urinary na, Ca Excretion and Hormonal Factors in Hypertensive and Normotensive Patients

고혈압과 정상혈압 환자에 있어서 Na, Ca 배설 및 관련 요인에 관한 연구

  • Published : 1995.04.01

Abstract

The aim of this study was to investigate the interrelationship among urinary excretion dietary habit of Na, Ca intake and hormonal factors in 22 hypertensive and 30 normotensive hospitalized patients. The results were summarized as follows : 1. Urinary excretion of Na in normotensive patients was not significantly different from that of hypertensive patients, while Ca excretion(as expressed on the basis of mg of creatinine) was significantly higher in hypertensive patients. 2. Habitual dietary intake of Na, Ca in hypertensive patients were not significantly different from those of normotensive patients. 3. There were no significant differences in mean plasma renin activity, aldosterone and parathyroid hormone(PTH) level between two groups. However, systolic pressure significantly correlated with PTH(r=0.2597) and aldosterone level(r=0.24648)(P<0.05). In this study blood pressure did not show any significant relationship between urinary Na excretion and habitual dietary Na intake of Na. It is speculated that individual difference of Na sensitivity might result in heterogenous blood pressure response to dietary Na intake. Higher Ca excretion in hypertensive subjects suggested a future study on the interrelationship between Ca metabolism and aldosterone system in hypertension.

Keywords

References

  1. 한국영양학회지 v.21 no.3 우리나라에서의 질병변천 최강원.
  2. 대한의학협회지 v.28 no.5 고혈압 성인에 대한 최근 학설 김삼수.
  3. 인간과학 v.4 no.12 sodium 섭취 및 배설과 고혈압 서순규.
  4. J. Lab. Clin Med. v.114 Calcium and hypertension Sowers,J.R.;Zemel,M.B.(et al.)
  5. Kidney,International v.35 Calcium metabolism and hypertension Cohen,J.J.;harrington,J.T.(et al.)
  6. 연세의대논문집 v.7 no.1 한국 정상인 및 본태성 고혈압 환자에 있어서의 Na 대사에 관한 연구 허갑범.;김인교.
  7. 인간과학 v.4 no.12 sodium 섭취 및 배설과 고혈압 서순규.
  8. 한국영양학회지 v.20 no.5 한국대학생의 sodium과 potassium 섭취량 및 대사에 관한 연구 박태선.;이기열.
  9. 한국인의 영양권장량 제5개정판 한국영양학회,한국보건연구원.
  10. 한국영양학회지 v.20 no.5 우리나라 성인의 Na 섭취량 측정방법의 모색 김영선.;백희영.
  11. 한국영양학회지 v.23 no.1 일부 산업체 근로자의 sodium섭취에 관한 연구 윤영옥.;김을상.;노희경.
  12. Am. J. Clin Nutr. v.25 Salt and hypertension Dahl,L.K.
  13. Arch. Intern. Med. v.146 Sodium and hypertension Huston Mc.
  14. Science v.224 Blood pressure and nutrient intake in the United States Macrron,D.A.;Morris,C.D.;Henry,H.J.;Stanton,J.L.
  15. Lancet v.1 Clinical and biochemical indicators of cardiovascular living in hard and soft water area Stitt,F.W.;Clcyton,D.G.;Crowford,M.D.
  16. JAMA v.4 Reduction of blood pressure with calcium supplementation in young adult Belizan,J.M.;Villar,J.;Pineda,O.
  17. Hypertension v.3 Disturbance of calcium metabolism in the SHR MaCarron,D.A.;Yung,N.N.;Ugoretz,B.A.Krutzik,S.
  18. Annals of Internal Med. v.107 The calcium deficiency hypothesis of hypertension MaCarron,D.A.;Morris,C.D.
  19. 한국영양학회지 v.21 no.4 칼슘의 보충섭취와 한국청년의 혈압에 미치는 영향 이정원.;김혜영.
  20. JAMA v.257 Blood pressure and metabolic effects of calcium supplementation in normotensive white and black males Lyle,R.M.;Melby,C.L.;Hyner,G.C.;Edmondson,J.W.;Miller,J.Z.;Weiberger,M.H.
  21. Am. J. Clin. Nutr. v.42 Effects on blood pressure of calcium supplementation of women Johnson,N.E.;Smith,E.L.;Freudenhein,J.L.
  22. Lancet v.2 Effect of calcium supplementation on diastolic blood pressure in young people with mild hypertension Grobbee,D.E.;Hofman,A.
  23. 국민영양조사보고서 보건사회부.
  24. 한국영양학회지 v.20 no.4 한국성인 여자에 있어서 나트륨 섭취수준이 체내 칼슘대사에 미치는 영향 김양애.;승정자.
  25. Am. J. Nephrol v.1 Urinary calcium excretion at extremes of sodium intake in Normal Man Macarron,D.A.;Rankin,L.I.;Bennett,W.M.
  26. 한국영양학회지 v.25 no.2 한국 젊은 성인여성과 중년여성의 소변중 Ca 배설과 이에 영향을 미치는 요인분석 조재현.;백희영.
  27. Nutr. Res. Rev. v.3 Sodium-calcium interrelationship will specific reference to osteopoprosis Shrott,C.;Flynn,A.
  28. Diabetescare v.14 no.6 Calcium metabolism in hypertension and allied metabolic disorders Resnick,L.M.
  29. Am. J. Physiol. v.232 no.3 Sodium ions, calcium ions, blood pressure resolution and hypertension Blaustein,M.P.
  30. Hypertensionin Salt sensitivity Sullivan,J.M.
  31. 노년기 여성에 있어서 칼슘섭취량, 에스트겐 수준 및 활동량이 골격상태에 미치는 영향(박사논문) 김혜경.
  32. 섭취빈도법을 이용한 성인 남녀의 Na,Ca 섭취량과 소변중의 Na,Ca 배설량의 비교연구(석사논문) 임정현.
  33. Practical physiology chemistry(13th ed.) Hawk,P.B.;Oser,B.L.;Summerson,W.H.
  34. Clin. Chim. Acta. v.126 Improved determination of serum calcium with 2-cresolphtalein complexone Lorentzk.
  35. Clin. Exp. Pharm. physiol v.18 Calcium metabolism in elderly hypertensive patients : possible participation of exaggerated sodium, calcium and phosphate excretion Imaoka,M.;Morimoto,S.;Kitano,S.;Fukuo,F.;Ogihara,T.
  36. Am. J. Hypertens v.6 The blood pressure effects of calcium supplementation in humans of known sodium responsiveness Weinberger,M.H.;Wagner,U.L.;Fineberg,N.S.
  37. Hypertension v.16 Calcitropic Hormones platelet calcium and Blood pressure in Essential Hypertension Arnold,S.;Brickman.;Michael,D.;Myby,P.
  38. Nutrition Today Calcium and Hypertension : Dose a Relationship Exist Kristine clark.
  39. Br.Med.J. v.296 Raised plasma intact parathyroid hormone concentrations in young people with mildly raised blood pressure Grobbee,D.E.;Hackeng,W.H.L.;Birkenhager,J.C.;Hofman,A.
  40. 동아시아식생활학회지 v.3 no.2 정상인과 고혈압 환자에 있어서 나트륨과 칼슘의 섭취와 배설에 관한 비교 연구 임정현.;윤진숙.
  41. 한국영양학회지 v.25 no.2 폐경기전 40대 한국여성들의 영양섭취상태와 골밀도와의 관계 이종호.;최미숙.;백인경.;문수재.;임승길.;안광진.;송영득.;이현철.;허갑범.
  42. 도시와 농촌지역 성인 남여의 식이 섭취와 골격간의 상호관계(석사논문) 공영애.