Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Hydrolysable Tannins and Related Compound having Cytotoxic Activity from the Fruits of Terminalia chebula

  • Lee, Seung-Ho (Korea Research Institute of Chemical Technology) ;
  • Ryu, Shi-Yong (Korea and College of Pharmacy, Yeungnam University) ;
  • Choi, Sang-Un (Korea and College of Pharmacy, Yeungnam University) ;
  • Lee, Chong-Ock (Korea and College of Pharmacy, Yeungnam University) ;
  • No, Zaesung (Korea and College of Pharmacy, Yeungnam University) ;
  • Kim, Seong-Kie (Korea and College of Pharmacy, Yeungnam University) ;
  • Ahn, Jong-Woong (Korea and College of Pharmacy, Yeungnam University)
  • Published : 1995.04.01
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Abstract

The cytotoxicity-directed fractionation of MeOH extract of Terminalia chebula fruits led to the isolation of three hydrolyzed tannins and a related compound, gallic acid(1), $1,2,3,4,6-penta-O-galloy-{\beta}-_D/-glucopyranose(II)$,. chebulagic acid (III) and chebulinic acid(IV), as active principles. They were shoen to exhibit moderate cytotoxicity against cultured human tumor cell lines including A-549, SK-OV-3, Sk-MEL-2, XF-498 and HCT-15 in vitro.

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