Inclusion Complexation of Clonixin with Cyclodextrins

클로닉신과 시클로덱스트린과의 포접복합체 형성

  • Park, Sun-Joo (College of Pharmacology, Ewha Womans University) ;
  • Kim, Kil-Soo (College of Pharmacology, Ewha Womans University)
  • 박선주 (이화여자대학교 약학대학) ;
  • 김길수 (이화여자대학교 약학대학)
  • Published : 1995.12.20

Abstract

The aim of this study is to increase the solubility and dissolution rate of clonixin by inclusion complex formation. Inclusion complexes of clonixin, a non-steroidal antiinflammatory drug, with ${\beta]-cyclodextrin$ were $2-hydrolrypropyl-{\beta]-cyclodextrin$ were prepared by freeze drying method. Inclusion complex formation of clonixin with cyclodextrins was determined by UV, IR and DSC. The apparent stability constants were calculated from the phase solubility diagrams. Dissolution rate and solubility of clonixin in water markedly increased by the complex formation.

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