Journal of Pharmaceutical Investigation
- Volume 25 Issue 4
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- Pages.291-298
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- 1995
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effect of Food on Ampicillin Absorption in the Rat Intestine
흰쥐의 소장에서 음식물이 암피실린의 흡수에 미치는 영향
- Lee, Hyun-Joo (College of Pharmacology, Catholic University of Taegu-Hyosung) ;
- Lee, Jeong-Hwa (College of Pharmacology, Catholic University of Taegu-Hyosung) ;
- Kwon, Yong-Zun (College of Pharmacology, Catholic University of Taegu-Hyosung) ;
-
Yang, Chae-Ha
(College of Oriental Medicine, Kyungsan University) ;
- Oh, Doo-Man (College of Pharmacology, Catholic University of Taegu-Hyosung)
- 이현주 (대구효성가톨릭대학교 약학대학) ;
- 이정화 (대구효성가톨릭대학교 약학대학) ;
- 권용준 (대구효성가톨릭대학교 약학대학) ;
-
양재하
(경산대학교 한의과대학) ;
- 오두만 (대구효성가톨릭대학교 약학대학)
- Published : 1995.12.20
Abstract
The purpose of this study is to verify the interaction between food and ampicillin which is one of the aminopenicillins known to be absorbed by a specified dipeptide transporter in the small intestine. The absorption of ampicillin was measured in the presence of the high carbohydrate food, high fat food, and high protein food, and compared with that in the presence of the control normal food. In situ single-pass perfusion method was chosen in these experiments using two jejunal segments in the rat. Reduction in the absorption of ampicillin was not shown, when both high carbohydrate food and high fat food were co-perfused with ampicillin. When the high protein food was co-perfused with ampicillin, the difference of