Journal of Pharmaceutical Investigation
- Volume 25 Issue 2
- /
- Pages.125-128
- /
- 1995
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Effect of Fatty Alcohols on Skin Permeation of Flurbiprofen
지방산 알코올이 플루르비프로펜의 피부투과에 미치는 영향
- Kim, Hyun (College of Pharmacy, Sung Kyun Kwan University) ;
-
Park, Eun-Seok
(College of Pharmacy, Sung Kyun Kwan University)
;
-
Chi, Sang-Cheol
(College of Pharmacy, Sung Kyun Kwan University)
- Published : 1995.06.20
Abstract
To increase the skin permeation rate of flurbiprofen, fatty alcohols were added in propylene glycol vehicle containing 1% flurbiprofen. Their enhancing effect on the skin permeation of flurbiprofen was evaluated using Keshary-Chien diffusion cells fitted with excised rat skins. Lauryl alcohol and oleyl alcohol increased the skin permeation rate of flurbiprofen 11.3 and 8.5 fold, respectively, compared to the control vehicle.