Journal of Pharmaceutical Investigation
- Volume 25 Issue 2
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- Pages.109-116
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- 1995
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Controlled Release Dosage Form of Narcotic Antagonist(I): Synthesis of Biodegradable Polyphosphazenes and Preparation and Release Characteristics of Naloxone Implant
마약길항제의 방출 제어형 제제 (제1보) : 생체분해성 polyphosphazenes의 합성과 나록손 이식제제의 제조 및 용출특성
- Park, Joo-Ae (College of Pharmacy, Ewha Womans University) ;
- Lee, Seung-Jin (College of Pharmacy, Ewha Womans University) ;
- Kim, Hyung-Kuk (National Institute of Health) ;
- Kim, Kil-Soo (College of Pharmacy, Ewha Womans University)
- Published : 1995.06.20
Abstract
For the administration of narcotic antagonist with short half-life and low patient compliance, the sustained release system using biodegradable matrix is effective. Polyphosphazenes are of considerable interest as biodegradable matrix systems for controlled release of drugs. In this study, biodegradable polyphosphazenes available for the sustained release implantable device were synthesized, and their application was examined. Poly[dichlorophosphazene] was synthesized by solution polymerization method and confirmed with IR spectrum. Poly[bis(ethyl glycinate) phosphazene] and poly[ (diethyl glutamate)-co-(ethyl glycinate)phosphazene] were then produced by substitution of amino acid alkyl esters for chloride side groups. Using these polymers, the implantable devices of 1 mm thickness and