Korean Journal of Food Science and Technology (한국식품과학회지)
- Volume 27 Issue 6
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- Pages.1003-1007
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- 1995
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- 0367-6293(pISSN)
Effect of Brown Rice Extract on Mitomycin C-Induced Chromosome Aberration in Cultured CHL Cells
현미 추출물이 Mitomycin C로 유발된 CHL 세포의 염색체 이상에 미치는 영향
- Chun, Hyang-Sook (Rice Utilization Research Center, Korea Food Research Institute) ;
- Kim, In-Ho (Rice Utilization Research Center, Korea Food Research Institute) ;
- Kim, Hyun-Jung (Rice Utilization Research Center, Korea Food Research Institute)
- Published : 1995.12.31
Abstract
The effect of brown rice extract on mitomycin C(MMC)-induced chromosome aberration was examined in cultured Chinese hamster lung(CHL) cells, after induction of chromosome aberration and mitotic index in CHL cells cultured with MMC were observed. There were no significant differences between mitotic indices of CHL cells treated with DMSO, and MMC and brown rice extract. The frequency of chromosome aberration showed dose-dependent relationship in CHL cells treated with
포유동물 세포인 CHL세포를 대상으로 MMC를 농도별로 투여하여 세포분열지수 및 염색체 이상 유발 및 그 양반응관계를 관찰하고 현미 추출물이 MMC에 의한 염색체 이상 빈도에 미치는 영향을 살펴보았다. 1. 대조군인 DMSO처리구에 비해 MMC 및 현미 추출물 투여에 의해 CHL세포의 세포분열 지수는 차이가 나타나지 않았다. 2. CHL 세포를 대상으로 MMC의 농도를