Archives of Pharmacal Research
- Volume 18 Issue 3
- /
- Pages.164-168
- /
- 1995
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Cytotoxicities of Ginseng Saponins and their Degradation Products against some Cancer Cell Lines
- Baek, Nam-In (Korea Ginseng & Tobacco Research Institute) ;
- Kim, Dong-Seon (Department of Biochemistry, Chungnam National University) ;
- Lee, You-Hui (Korea Ginseng & Tobacco Research Institute) ;
- Park, Jong-Dae (Korea Ginseng & Tobacco Research Institute) ;
- Lee, Chun-Bae (Department of Biochemistry, Chungnam National University) ;
- Kim, Shin-Il (Korea Ginseng & Tobacco Research Institute)
- Published : 1995.06.01
Abstract
In order to elucidate the cytotoxicity-structure correlation of ginseng-derived components, several prosapogenins and sapogenins were prepared from Korean red ginseng (Panax ginseng) saponins by acid hydrolysis or alkaline cleveage, and their chemical structures were identified by a combination of spectral and physical methods. Some of these degradation products showed the cytotoxic activities against various cancer cell lines, A549, SK-OV-3, SK-Mel-2, P388, L1210 and K562. The significant difference in cytotoxicity between stereoisomers was not found and the activity was inversely proportional to the number of sugars linked to sapogenins. Diol-type prosapogenins and sapogenins showed higher cytotoxicity than triol-type ones.
Keywords
- Panax ginseng;
- Cytotoxicity;
- Ginsenosides;
- Prosapogenins;
- Sapogenins;
- Structure-cytotoxicity Relationship