Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Insulin Resistance in Obese and Non-obese Patients with Polycystic Ovarian Syndrome

다낭성 난소 증후군 환자에서 비만군과 비비만군에서의 인슐린 저항성

  • Lim, Y.K. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Lee, B.S. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Cho, E.J. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Cha, D.H. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Park, W.I. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Park, K.H. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Cho, D.J. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Lee, K. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Song, C.H. (Department of Obstesterics and Gynecology, Yonsel University College of Medicine) ;
  • Lee, E.J. (Department of Internal Medicine Yonsel University College of Medicine)
  • 임영구 (연세대학교 의과대학 산부인과학교실) ;
  • 이병석 (연세대학교 의과대학 산부인과학교실) ;
  • 조은정 (연세대학교 의과대학 산부인과학교실) ;
  • 차동현 (연세대학교 의과대학 산부인과학교실) ;
  • 박원일 (연세대학교 의과대학 산부인과학교실) ;
  • 박기현 (연세대학교 의과대학 산부인과학교실) ;
  • 조동제 (연세대학교 의과대학 산부인과학교실) ;
  • 이국 (연세대학교 의과대학 산부인과학교실) ;
  • 송찬호 (연세대학교 의과대학 산부인과학교실) ;
  • 이은직 (연세대학교 의과대학 내과학교실)
  • Published : 1994.04.30
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Abstract

This study was designed to investigate the relationship between insulin resistance and obesity in the pathogenesis of polycystic ovarian syndrome(PCO). Twenty-two women with PCO, of whom thirteen were non-obese with body mass index(BMI, kg/$m^2$) of <25 and nine were obese with BMI${\geq}$25 were studied. Eight non-obese control women and seven obese control women were studied. Serum concentrations of testosterone, lutenizing hormone(LH)/follicle-stimulating hormone(FSH) ratio, and insulin-like growth factor I (IGF-I) were found to be significantly higher(P<0.05) in PCO women compared with control women, which clearly is not related to obesity. Serum glucose, insulin, and C-peptide levels were measured during a 2-hour oral glucose tolerance test(OGTT). Non-obese and obese women with PCO both(P<0.05) compared with control women demonstrated significant hyperinsulinemia after OGTT. The degree of hyperinsulinemia was found to be significantly higher in the obese women with PCO compared with the non-obese women with PCO. We concluded that obesity may contribute to hyperinsulinemia, however may not playa central role in the pathogenesis of PCO.

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