Archives of Pharmacal Research
- Volume 17 Issue 4
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- Pages.249-255
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- 1994
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
A Novel Synthetic Route to 11-Deoxyanthracycline AB Synthons
- Kim, Hee-doo (College of Pharmacy, Sookmyung Womens University) ;
- Park, Sang-Ae (College of Pharmacy, Sookmyung Womens University) ;
- Jew, Sang-Sup (College of Pharmacy, Seoul National University)
- Published : 1994.08.01
Abstract
An efficient synthetic method for 11-deoxyanthracycline AB synthons is described. A verstile key intemediate vinyl bromide 3 was prepared from 5- methodxy-1-tetralone in three steps, and then was converted to the allylic alcohols 4 and 8 which, in tum, fumished highly fuctionalized AB synthons 7 and 12, respectively, via sequential epoxidation-reduction-protection processes.
Keywords
- 11-Deoxyanthracycline;
- AB synthon;
- Vinyl bromide;
- Allylic alcohol;
- Epoxidation;
- 5-Methoxy-1-teralone