Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of Lipophilic Fraction and Protein Fraction of Korean Red Ginseng on the Production of cGMP In Rat Platelets

Rat 혈소판의 cGMP생성에 있어서 홍삼 지용성 분획과 단백질 분획의 영향

  • Lee, Man-Hee (Department of Biochemistry Pharmacology, Korea Ginseng & Tobacco Research Institute) ;
  • Lee, Jung-Hee (Department of Food and Nutrition, Ewha Womans University) ;
  • Park, Hwa-Jin (Department of Biochemistry Pharmacology, Korea Ginseng & Tobacco Research Institute)
  • 이만휘 (한국인삼연초연구원 인삼효능부) ;
  • 이정희 (이화여자대학교 식품영양학과) ;
  • 박화진 (한국인삼연초연구원 인삼효능부)
  • Published : 1994.08.01
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Abstract

Rats (Sprague Dawley, male, 200 g) were fed with 15% corn oil containing a large quantity of 18 2 (linoleic acid) for 3 weeks, and were followed by feeding the petroleum ether extracts from Korean red ginseng for 3 weeks. cGMP was produced more in platelets prepared from both 15% corn oil and petroleum ether extracts-fed group than in platelets only 15% corn oil-fed group, indicating that the production of cGMP is increased by feeding the petroleum ether extracts. When this platelet was stimulated by phorbol-12-myristate-13-acetate (PMA), the level of cGMP was decreased. However, the platelets in medium containing protein fraction (200 $\mu\textrm{g}$/ml) was stimulated by PMA, the production of cGMP inhibited by PMA was increased by 3 times or more. These results suggest that both the protein fraction and the petroleum ether extracts from Korean red ginseng are synergistic in the productiorl of cGMP, and they may have the antiplatelet effects.

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