The Korean Journal of Pharmacology (대한약리학회지)
- Volume 30 Issue 2
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- Pages.243-254
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- 1994
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- 0377-9459(pISSN)
The Effects of Single Component of Ginsenosides on the Mechanism of Mediator Release in the Allergic Hypersensitivity
인삼 사포닌 단일물질이 알러지 과민반응의 매개체 유리기전에 미치는 영향
- Ro, Jai-Youl (Department of Pharmacology, Yonsei University College of Medicine) ;
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Kim, Kyung-Hwan
(Department of Pharmacology, Yonsei University College of Medicine)
- Published : 1994.09.30
Abstract
Inflammatory diseases, allergic and asthmatic disorders are caused by the mediator release from the activation of the phospholipase C (PLC), phospholipase D (PLD), methyltransferase or adenylate cyclase etc. during IgG or IgE cross-linking of high affinity receptors on mast cells or basophil surface. One important enzyme activated after IgG or IgE receptor cross-linking is PLD, the enzyme which converts phosphatidylcholine (PC) to phosphatidic acid (PA). Under the hypothesis that these may be some differences in mediator release according to the difference in PLD activity, we attempted to confirm the ginseng saponin effects on the PLD activity. We examined the PLD activity during the passively sensitized mast cell activation in the presence of single component of ginsenosides