약학회지 (YAKHAK HOEJI)
- 제38권5호
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- Pages.602-607
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
신장 조직의 브라디키닌 결합부위 발현
Expression of Bradykinin Binding Sites within the Mammalian Kidney Tissues
- Chung, Sung-Hyun (College of Pharmacy, Kyunghee University) ;
- Jung, Jee-Chang (College of Medicine, Kyunghee University)
- 발행 : 1994.10.30
초록
Based upon the previous experiments showing that kidney and lung tissues of rat had relatively abundant bradykinin binding sites, we tried to characterize and determine the densities of the bradykinin binding sites in the rabbit kidney tissue and proximal tubular cells under different growing conditions. Among the kidney tissue renal medulla segments showed the highest bradykinin binding sites. To determine which growth factors are to add in the serum free culture medium to express selectively the bradykinin binding sites in the rabbit kidney proximal tubular cells, we tried so called hormone-deletion approach and in here insulin, hydrocortisone, transferrin, triiodothyronine and prostaglandin