YAKHAK HOEJI (약학회지)
- Volume 38 Issue 3
- /
- Pages.338-344
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
The Antifibrotic Effects of Polysaccharides Extracted from Garnoderma lucidum on the Experimental Hepatic Cirrhosis
영지로부터 추출한 다당체의 실험적 간경화에 대한 섬유화 억제효과
-
Park, Eun-Jeon
(College of Pharmacy, Wonkwang University)
;
-
Kim, Ki-Young
(Institute of Pharmaceutical Research & Development, Wonkwang University)
;
- Kim, Jae-Baek (College of Pharmacy, Wonkwang University) ;
- Kim, Soo-Woong (Il Yang Pharm. Co., Ltd., Central Research Center) ;
- Lee, Seung-Yong (Il Yang Pharm. Co., Ltd., Central Research Center) ;
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Sohn, Dong-Hwan
(College of Pharmacy, Wonkwang University)
-
박은전
(원광대학교 약학대학)
;
-
김기영
(원광대학교 약품연구소)
;
- 김재백 (원광대학교 약학대학) ;
- 김수웅 (일양약품(주) 중앙연구소) ;
- 이승룡 (일양약품(주) 중앙연구소) ;
-
손동환
(원광대학교 약학대학)
- Published : 1994.06.30
Abstract
This study was carried out to investigate the antifibrotic effects of polysaccharides extracted from Garnoderma lucidum. The biliary cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats were dosed 5 mg/rat/day orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, serum procollagen type III peptide (PIIINP) levels, liver hydroxyproline contents, and light microscopical histology. The results obtained were as follows; 1) PIIINP levels in sera of treated BDL/S group were lowered to 50% of those of untreated BDL/S group. 2) Hydroxyproline contents in the liver of treated BDL/S group were also reduced to 83% of those of untreated BDL/S rats. 3) The hepatic damage such as hepatocellular necrosis, inflammation, bile duct proliferation and fibrosis was less severe in the livers of treated rats. These results suggest polysaccharides extracted from Garnoderma lucidum to be a promising agent for the inhibition of hepatic cirrhosis(fibrosis).