약학회지 (YAKHAK HOEJI)
- 제38권3호
- /
- Pages.281-285
- /
- 1994
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Melandrin 유도체의 합성
Synthesis of Melandrin Derivatives
- Lim, Jung-Ki (College of Pharmary, Sung Kyun Kwan University) ;
- Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
- Lee, Kang-Ro (College of Pharmary, Sung Kyun Kwan University) ;
- Ma, Eun-Sook (College of Pharmary, Hyosung Women's University)
- 발행 : 1994.06.30
초록
Melandrin was isolated from the Melandrium firmum(Caryophyllaceae), its structure was N-(p-hydroxybenzoyl)-5-hydroxyanthranilic acid. Fourteen melandrin derivatives(I-XIV) were synthesized and according to MME calculation by the computer, optimized three dimensional structure of compounds was obtained. The space orientation of compounds was cis-form as a indomethacin.