Journal of Yeungnam Medical Science
- 제10권2호
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- Pages.432-444
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- 1993
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- 2799-8010(eISSN)
항암제에 내성인 생쥐의 백혈병세포 L1210의 세포막 단백질의 변환
Membrane Protein Alterations Associated with Anticancer Drug Resistance in Mouse Lymphoblastic Leukemia L1210 Cells
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Kim, Seong-Yong
(Department of Biochemistry College of Medicine, Yeungnam University) ;
- Son, Sung-Kweon (Department of Biochemistry College of Medicine, Yeungnam University) ;
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Kim, Jae-Ryong
(Department of Biochemistry College of Medicine, Yeungnam University) ;
- Kim, Jung-Hye (Department of Biochemistry College of Medicine, Yeungnam University)
- 발행 : 1993.12.30
초록
Adriamycin과 vincristine 각각에 내성인 생쥐의 림프아세포성 백혈병세포 L1210세포의 특성과 내성관계 단백질을 찾아내고 항암제의 세포내 분포를 관찰하였다. 항암제의 내성생성은 adriamycin이
Multidrug resistance(MDR) phenotype is frequently observed in animal and human cancer cell lines selected for in vitro resistance to a single chemotherapeutic agent. It is characterized by the diminished drug accumulation and is related to the drug efflux mechanism in resistant cells. In the present study, adriamycin resistant cells(L1210-