Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

THE EFFECTS OF CHLORHEXIDINE ON THE ATTACHMENT AND GROWTH OF CULTURED HUMAN GINGIVAL FIBROBLASTS IN VITRO

인체 치은 섬유아세포의 성장과 부착에 관한 Chlorhexidine의 효과

  • Lee, Ho (Dept. of Periodontology, College of Dentistry, Chonbuk National University) ;
  • Lee, In-Kyu (Dept. of Periodontology, College of Dentistry, Chonbuk National University) ;
  • Kim, Hyung-Seop (Dept. of Periodontology, College of Dentistry, Chonbuk National University)
  • 이호 (전북대학교 치과대학 치주과학교실) ;
  • 이인규 (전북대학교 치과대학 치주과학교실) ;
  • 김형섭 (전북대학교 치과대학 치주과학교실)
  • Published : 1993.11.30
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Abstract

The Chlorhexidine(CHX) has been a widely used adjunt in periodontal therapy due to its bactericidal effect. In spite of the effects of CHX exhibits cytotoxic to human cells and delays granulation tissue formation. Therefore, understanding the effects of CHX on fibroblast attachment and cell growth will provide the rationale for its use during healing phase of periodontal surgery. This study was undertaken to examine the effects of standardized CHX-pretreated dentin slices and direct CHX exposure on human gingival fibroblasts. The results were as follow : 1. In experiment 1, there was a significant reduction in the number of fibroblast attachment in 0.12, 1%-pretreated groups relative to the control, 0.05%-pretreated groups(P<0.05). 2. In experiment 1, the control, 0.05%-pretreated groups showed considerable attachment and typical fibroblastic morphology, but 0.12, 1%-pretreated groups showed irregular, round-up (unattached) fibroblastic morphology. 3. In experiment 2, it appeared that all experimental groups exhibits significant inhibition of cell growth when compared with the control group.

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