Acute Oral Toxicity Studies of WHS-1 and WHS-2 in Rats

경구용 복합제 WHS-1,2의 급성독성시험 연구

  • 조대현 (국립보건안전연구원 독성부) ;
  • 황세진 (국립보건안전연구원 독성부) ;
  • 이원용 (국립보건안전연구원 독성부) ;
  • 이주영 (한일약품(주) 중앙연구소) ;
  • 윤형중 (한일약품(주) 중앙연구소) ;
  • 문병우 (한일약품(주) 중앙연구소)
  • Published : 1993.12.01

Abstract

Single oral administration to SD rats of both sexes were performed to investigate the acute toxicity of two new cough and cold remedies, WHS-1 and WHS-2. WHS-1 is composed of acetaminophen, chlorpheniramine maleate, cloperastine hydrochloride, dl-methylephedrine hydrochloride, caffein anhydrous, thiamine hydrochloride, riboflavin and serratiopeptidase. WHS-2 is composed of similar formula except that thiamine hydrochloride and riboflavin is not added. The results were as follows. $LD_{50}$ values of WHS-1 were 4295.5 mg/kg for males and 4606.3 mg/kg for females, and $LD_{50}$ values of WHS-2 were 3236.7 mg/kg for males and 4360.5 mg/kg for females. Death occurred within 2~3 hours after administration at doses up to 2900 mg/kg in WHS-1 and 2500 mg/kg in WHS-2, the main cause of deaths seemed to be respiratory disturbance. General symptoms included decreased motor activity, salivation and loss of consciousness which were commonly observed in all dead animals treated with WHS-1 and WHS-2. No significant gross finding and body weight changes were observed at any dose level in the groups treated with WHS-1 and WHS-2.

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