Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지

Acute Toxicity Study of Recombinant Granulocyte-Macrophage Colony Stimulating Factor (LBD-005) in ICR mice

  • Kim, Hyoung-Chin (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Song, Si-Whan (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Cha, Shin-Woo (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Shin, Chun-Chul (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Ha, Chang-Su (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Han, Sang-Seop (Toxicology Research Center, Korea Research Institute of Chemical Technology)
  • Published : 1993.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The acute toxicity of a recombinant granulocyte-macrophage colony stimulating factor (code name: LBD-005) was evaluated in both sexes of ICR mice, 5~6 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results of the acute toxicity study, LBD-005 was not considered to induce any toxic effect on the mice in mortalities, clinical findings, body weights and gross findings. It is suggested that $LD_50$ values in mice would be >48 mg/kg in the oral route and >24 mg/kg in the subcutaneous or intravenous route.

Keywords