Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지

The Production of Foreign Protein in Mouse L Cell

Mouse L Cell에서의 외래 유전자 유래 단백질의 생산

  • 최윤희 (서울대학교 공과대학 생물화학공학 협동과정) ;
  • ;
  • 최차용 (서울대학교 공과대학 화학공학과)
  • Published : 1993.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Some interleukin 6 (IL-60 transcription control factors were resported as the regulator of IL-6 expression. A nuclear protein bound to interleukin 1 (IL-1) responsive element in the IL-6 promoter region was named NF-IL6 (nuclear factor for IL-6). This NF-IL6 was known to be very imporant as a transcription factor for various immuno-protein as well as for IL-6. The human NF-IL6 genes were transfected into the mouse L cells under the metallothionein promoter (MT promoter) to establish a model system for the expression of foreign gene in the mammalian cell line.

Keywords

References

  1. Immunol. Today v.7 Draft proposals for interleukin nomenchature Smith,K.A.
  2. Nature v.324 Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin Hirano,T.;K.Yasukawa;H.Harada;T.Taga;Y.Waaanabe;A.Iwamatsu;S.Tsunasawa;F.Sakiyama;H.Matsui;Y.Takahara;T.Taniguchi;T.Kishimoto
  3. EMBO J. v.5 Structure and expression of cDNA and genes for human interferon-beta-2, a distince species inducible by growth-stimulatory cytokines Zilberstein,A.;R.Ruggieri;J.H.Korn;M.Revel
  4. Blood v.74 The biology of interleukin-6 Kishimoto,T.
  5. Proc. Natl. Acad. Sci. USA. v.84 Human B cell differentiation factor defined by an antipeptide antibody and its possible role in autoantibody production Hirano,T.;T.Taga;K.Yasukawa;K.Nakajima;N.Nakano;F.Takatsuki;M.Shimizu;A.Murashima;S.Tsunasawa;F.Sakiyama;T.Kishimoto
  6. J. Immunol. v.141 Regulation of BSF-2/IL-6 production by human mononuclear cells:macrophagedependent synthesis of BSF-2/IL-6 by T cells Horii,Y.;A.Muraguchi;S.Suematsu;T.Matsuda;K.Yoshizaki;T.Hirano;T.Kishimoto
  7. Eur. J. Immunol. v.18 Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis Hirano,T.;T.Matsuda;M.Turner;N.Miyasaka;G.Buchan;B.Tang;K.Sato;M.Shimizu;R.Maini;M.Feldman;T.Kishimoto
  8. Immunol. Lett. v.24 Interleukin-6:historical background, genetics and biological significance Wolvekamp,M.C.J.;R.L.Marquet
  9. EMBO J. v.9 A nuclear factor for IL-6 expression (NF-IL6)is a member of a C/EBP family Akira,S.;H.Isshiki;T.Sugita;O.Tanabe;S.Kinoshita;Y.Nishio;T.Nakajima;T.Hirano;T.Kishimoto
  10. Cell Technology v.9 IL-6 gene regulation and signal transduction via IL-6 recepter Akira,S.
  11. Eur. J. Immunol. v.18 Estiblishment of mouse cell lines which constituticely secreat large quantities of interleukin 2,3,4, or 5, using modified cDNA expression vectors Karasuyama,H.;F.Melchers
  12. Molecular Cloning Sambrook,J.;E.F.Fritsch;T.Maniatis
  13. Eur. J. Immunol. v.20 Microheterogeneity of human interleukin 6 synthesized by transfected NIH/3T3 cells: comparison with human monocytes. fibroblasts and endotherial cells Schiel,X.;S. Rose-John;G.Dufhues;H.Schooltink;V.Gross;P.C.Heinrich