Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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EFFECTS OF BHA AND ACETAMINOPHEN ON THE BILIARY EXCRETION OF PHENOLPHTHALEIN AND THE HEPATIC GLUCURONIDATION IN MALE RATS

  • Published : 1993.12.01
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Abstract

The present study examined the effects of butylated hydroxyanisole (BHA) on acetaminophen (AA)-induced hepatotoxicity in male rats and also examined the effects of these compounds on the biliary excretion of phenolphthalein (PP) and the hepatic glucuronidation. Male Sprague-Da-wley rats were pretreated with BHA (0.75% in diet for 10 days) were given single dose of AA (600mg/kg, ip) and liver function was determined 24 hr later. Serum activity of alanine aminotransferase (ALT) and histopathology were used as indices of hepatotoxicity.

Keywords

References

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