YAKHAK HOEJI (약학회지)
- Volume 37 Issue 1
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- Pages.36-40
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- 1993
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of 4-(2'-(N-(1-methyl-3'-carbamylphenyl)-n-propyl))aminoethyl)-1-hydroxy-2-pyridone
4-(2'-(N-(1-메틸-3-(3'-카바밀페닐)-n-프로필))아미노에틸)-1-히드록시-2- 피리돈의 합성
Abstract
The 4-(2'-(N-(l-methyl-3'-carbamylphenyl)-n-propyl))aminoethyl)-l- hydroxy-2-pyridone which has isoelectronic and isosteric structural similarity with dobutamine without having the Catechol-O- Methyltransferase(COMT) vulnerable m-hydroxy group was synthesized via 12 synthetic steps.