YAKHAK HOEJI (약학회지)
- Volume 37 Issue 1
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- Pages.18-29
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- 1993
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Antimutagenic Effect of Organic Germanium(GE-132) on the Mutagenicity of Benzo(a)pyrene
Benzo(a)pyrene의 돌연변이원성에 대한 유기게르마늄(GE-132)의 항돌연변이 효과
- Lee, Hyo-Min (College of Pharmacy, Duksung Woman's University) ;
- Chung, Yong (The Institute for Environmental Research, Yonsei University) ;
- Jung, Ki-Wha (College of Pharmacy, Duksung Woman's University) ;
- Kim, Jae-Wan (College of Pharmacy, Duksung Woman's University) ;
- Kwon, Sun-Kyung (College of Pharmacy, Duksung Woman's University)
- 이효민 (덕성여자대학교 약학대학) ;
- 정용 (연세대학교 환경공해연구소) ;
- 정기화 (덕성여자대학교 약학대학) ;
- 김재완 (덕성여자대학교 약학대학) ;
- 권순경 (덕성여자대학교 약학대학)
- Published : 1993.02.01
Abstract
This study was initiated to investigate the effective action and mechanism of GE-132 (Carboxyethylgermanium sesquioxide)on benzo(a)pyrene, which have strong carcinogenicity and mutagenicity. To confirm desmutagenic effect (inhibition of metabolic processes of benzo(a)pyrene with S9 Mix or inactivation of the mutagenicity of benzo(a)pyrene metabolites) and antimutagenic effect (inhibition of gene-expression of reverted genes) of GE-132 against benzo(a)pyrene using with Salmonella typhimuyium TA98 Ames test was performed. The revertants in desmutagenicity test were decreased significantly in the combined groups of benzo(a)pyrene and GE-132 than benzo(a)pyrene only, without inhibition the metabolism of benzo(a)pyrene by S9 Mix. The ideal combined groups of benzo(a)pyrene and GE-132 were 10