Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Particle Size Distribution and Stability of Lipid Emulsion in Total Nutrient Admixtures

Total Nutrient Admixtures(TNAs)에서 지질유제의 입자크기 분포 및 안정성

  • Park, Seung Mi (Department of Pharmacy, Seoul National University Hospital) ;
  • Jang, Eun Ju (Department of Pharmacy, Seoul National University Hospital) ;
  • Shin, Wan Gyoon (Department of Pharmacy, Seoul National University Hospital) ;
  • Lee, Byung Koo (Department of Pharmacy, Seoul National University Hospital) ;
  • Lee, Min Wha (College of Pharmacy, Seoul National University)
  • Published : 1993.12.01
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Abstract

The particle size distribution and physical stability of commercial lipid emulsion inject, $intralipos^R$ before and after mixture with total parenteral nutrition(TPN) was tested. Three TNAs were prepared by adding intralipos to P-TPN, Neo-TPN and IVH-2 respectively. Particle size of fat emulsion in three TNA preparations were measured by using LPA-3000 photon correlater. Each TNAs was stored for 48 hours at $4^{\circ}C\;and\;25^{\circ}C.$ During storage, three TNAs showed the particle size in the range of 40-1000nm(about $100\%$ of total fat) and in the range of 1000-8000nm(less than $0.005\%$ of total fat). All TNAs were stable in terms of pH and visual appearance. The results showed that added lipid emulsion was stable for 48 hours at $4^{\circ}C\;and\;25^{\circ}C$.

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