Journal of Pharmaceutical Investigation
- Volume 23 Issue 3
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- Pages.119-125
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- 1993
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
The Effect of Physicochemical Properties of Salicylate Analogs on Binding to Bovine Serum Albumin
살리실산 유사체류의 물성이 우혈청 알부민 결합에 미치는 영향
Abstract
The protein binding of salicylate analogs has been investigated by equilibrium dialysis. A series of binding experiments were performed in order to elucidate the effects of physicochemical properties of salicylate analogs on the binding with bovine serum albumin. Attempts to correlate affinity constants with capacity factor, steric factor and Hammett
Keywords
- Protein binding;
- Salicylate analogs;
- Equilibrium dialysis;
- Capacity factor;
- Steric factor;
- Electronic factor