Neuropharmacological Activity of Humulus lupulus Extracts

  • Lee, Kang-Mee (Sam Chun Dang Pharm. Co.) ;
  • Jung, Jun-Sub (Sam Chun Dang Pharm. Co.) ;
  • Song, Dong-Keun (Institute of Natural Medicine, Department of Pharmacology, College of Medicine, Hallym University) ;
  • Kim, Yung-Hi (Institute of Natural Medicine,Department of Pharmacology,College of Medicine,Hallym University)
  • Published : 1993.09.30

Abstract

Neuropharmacological profile of Humulus lupulus (hop) extract was studied in mice. At doses above 100 mg/kg(i.p.), it decreased spontaneous locomotor activity and raised the nociceptive threshold in the hot-plate test. At doses above 250 mg/kg (i.p.), it increased pentobarbital-induced sleeping time and produced muscle relaxant effect. At the dose of 500 mg/kg, anticonvulsive effect against pentylenetetrazole-induced convulsion and hypothermic effect was observed.

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