Korean Journal of Pharmacognosy (생약학회지)
- Volume 24 Issue 3
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- Pages.231-234
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- 1993
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Neuropharmacological Activity of Humulus lupulus Extracts
- Lee, Kang-Mee (Sam Chun Dang Pharm. Co.) ;
- Jung, Jun-Sub (Sam Chun Dang Pharm. Co.) ;
- Song, Dong-Keun (Institute of Natural Medicine, Department of Pharmacology, College of Medicine, Hallym University) ;
- Kim, Yung-Hi (Institute of Natural Medicine,Department of Pharmacology,College of Medicine,Hallym University)
- Published : 1993.09.30
Abstract
Neuropharmacological profile of Humulus lupulus (hop) extract was studied in mice. At doses above 100 mg/kg(i.p.), it decreased spontaneous locomotor activity and raised the nociceptive threshold in the hot-plate test. At doses above 250 mg/kg (i.p.), it increased pentobarbital-induced sleeping time and produced muscle relaxant effect. At the dose of 500 mg/kg, anticonvulsive effect against pentylenetetrazole-induced convulsion and hypothermic effect was observed.
Keywords
- Humulus lupulus L.(hop);
- hot-plate test;
- rotarod test;
- locomotor activity;
- sleep potentiation;
- hypothermia;
- anticonvulsant property