생약학회지 (Korean Journal of Pharmacognosy)

  • 제24권2호
  • /
  • Pages.124-130
  • /
  • 1993
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

지유로부터 분리한 다당류의 분석과 항응고작용

Compositional Analysis of Polysaccharide from Sanguisorba officinalis and Its Anticoagulant Activity

  • 김영식 (서울대학교 천연물과학연구소) ;
  • 노지은 (동덕여자대학교 약학대학) ;
  • 안형수 (동덕여자대학교 약학대학)
  • Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University) ;
  • Roh, Ji-Eun (College of Pharmacy, Dongduck Women's University) ;
  • Ann, Hyung-Soo (College of Pharmacy, Dongduck Women's University)
  • 발행 : 1993.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Polysaccharide from Sanguisorba officinalis was separated and fractionated using DEAE-Sephadex ion-exchange chromatography and Sephacry HR-200 gel filtration chromatography. One of the fraction(Fr. II) was sulfated and its anticoagulant activity was tested in vitro. Sulfation could increase the clotting time 50 times compared to unsulfated one. Fr. II was hydrolyzed and its composition was analyzed by conjugation with 7-amino-1, 3-naphthalene disulfonic acid using HPLC and electrophoresis. Arabinose and galactose were mainly composed at the ratio of 4 : 1. In addition, xylose and rhamnose were also found.

키워드