Korean Journal of Pharmacognosy (생약학회지)
- Volume 24 Issue 2
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- Pages.131-139
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- 1993
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Effects of the Extracts from Hoelen alba, Alismatis Rhizoma and Atractylodes Rhizoma on Proliferation and Differentiation of 3T3-L1 Cells
3T3-L1 세포(細胞)의 증식(增殖) 및 분화(分化)에 미치는 백복령(白茯笭), 택사(澤瀉) 및 창출(蒼朮)의 영향(影響)
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Eun, Jae-Soon
(Dept. of Pharmacy, Chunju Woo Suk University) ;
- Hong, Jong-Sung (Dept. of Pharmacy, Chunju Woo Suk University) ;
- So, June-No (Dept. of Biotechnology, Chunju Woo Suk University)
- Published : 1993.06.30
Abstract
These studies were conducted to investigate the effects of the extracts from Hoelen alba, Alismatis Rhizoma and Atractylodes Rhizoma on the proliferation and differentiation of 3T3-L1 cells. The results were summerized as follows: Hoelen alba and Alismatis Rhizoma extracts inhibited the proliferation of preadipose 3T3-L1 cells. In inductive differentiation, all three extracts inhibited the adipose conversion in 2 days of initial-culture, Atractylodes Rhizoma extract inhibited the adipose conversion in 5 days of final-culture and Hoelen alba and Alismatis Rhizoma inhibited adipose conversion in treatment of whole term of culture. In spontaneous differentiation, Atractylodes Rhizoma extract increased the adipose conversion in 2 days of initial-culture, Hoelen alba and Alismatis Rhizoma increased the adipose conversion in 5 days of final-culture, all three extracts increased adipose conversion in treatment of whole term of culture. The 10% serum of mice treated with each sample did not affect, but the 5% serum of them inhibited the proliferation of 3T3-L1 cells. In inductive differentiation, the 10% serum of them inhibited the adipose conversion in treatment of whole term of culture.
Keywords
- Hoelen alba;
- Alismatis Rhizoma;
- Atractylodes Rhizoma;
- 3T3-L1 cell proliferation;
- inductive differentiation;
- spontaneous differentiation;
- adipose conversion