임상약리학회지 (Journal of Korean Society for Clinical Pharmacology and Therapeutics)
- 1권1호
- /
- Pages.61-66
- /
- 1993
- /
- 1225-5467(pISSN)
Cisplatin과 5-Fluorouracil 병합항암요법을 받은 두경부 암환자에서 Ondansetron의 항구토 효과
The Antiemetic Effect of Ondansetron in Head and Neck Cancer Patients Receiving Chemotherapy with Cisplatin and 5-Fluorouracil
-
강진형
(가톨릭대학교 의과대학 내과학교실) ;
- 안유배 ;
- 문한림 (가톨릭대학교 의과대학 내과학교실) ;
- 홍영선 (가톨릭대학교 의과대학 내과학교실) ;
-
김춘추
(가톨릭대학교 의과대학 내과학교실) ;
-
이경식
(가톨릭대학교 의과대학 내과학교실) ;
- 김동집 (가톨릭대학교 의과대학 내과학교실) ;
- 조승호 (가톨릭대학교 의과대학 이비인후과학교실) ;
- 서병도 (가톨릭대학교 의과대학 이비인후과학교실) ;
- 김훈교 (가톨릭대학교 의과대학 내과학교실)
-
Kang, Jin-Hyung
(Department of Internal Medicine, Catholic University Medical College) ;
- Ann, Yu-Bae (Department of Internal Medicine, Catholic University Medical College) ;
- Moon, Han-Lim (Department of Internal Medicine, Catholic University Medical College) ;
- Hong, Young-Seon (Department of Internal Medicine, Catholic University Medical College) ;
-
Kim, Chool-Choo
(Department of Internal Medicine, Catholic University Medical College) ;
-
Lee, Kyung-Shik
(Department of Internal Medicine, Catholic University Medical College) ;
- Kim, Dong-Jip (Department of Internal Medicine, Catholic University Medical College) ;
- Cho, Seung-Ho (Department of ENT-Head & Neck Surgery Catholic University Medical College) ;
- Suh, Byung-Doe (Department of ENT-Head & Neck Surgery Catholic University Medical College) ;
- Kim, Hoon-Kyo (Department of Internal Medicine, Catholic University Medical College)
- 발행 : 1993.05.31
초록
저자들은 국소진행성 두경부암 환자에게
Background : Cispaltin is highy effective in the treatment of many cancers, but severe nausea and vomiting is main problem. Although high dose metoclopramide effectively prevents cisplatin-induced nausea and vomiting, extrapyramidal symptom frequently occurs. Ondansetron, selective antagonist of 5-HT3 receptor, is a new potent antiemetic without extrapyramidal symptom. Method : We prospectively evaluated the antiemetic effects of ondasetron administered 8 mg 3 times, intravenously during the first 24 hours and orally thereafter until the 6th day in 25 locally advanced hell and neck cancer patients who received cisplatin
키워드