대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제13권1호
  • /
  • Pages.55-64
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  • 1992
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  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지

Poly($\tau$-benzy1 L-glutamate)와 polyoxpropylene으로 된 블록 공중합체의 합성 및 약물방출특성

Synthesis of Block Copdymers Consistin(3 of Poly($\tau$-benzy1 L-glutamate) and Polyoxpropylene and Their Drug Release Behsviours

  • 강인규 (경북대학교 고분자공학과) ;
  • 김우식 (경북대학교 고분자공학과, 경북대학교 치과대학 치과재표학교실)
  • 발행 : 1992.03.01
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초록

AB -type block copolymers of poly($\tau$-benzyl L-glutamate) (PBLG, a segment) and polyoxypropylene (POP, Bsegment) were synthesized and they were reacted with polyoxypropylene his(6-aminohexyl) (POE) to enhance the hydrophilicity of the poly- mers. The degree of swelling of the POE -crosslinked block copolymers (CPB -2) was higher than that of the block dopolymers (PB). The amount of 5-fluorouracil re- leased from CPB-2 block copolymers was greater than that from the PB block copol- ymers when they were incubated in the same period. These results indicate that the amount of 5-fluorouracil released from the matrices is proportional to the hydrophilicity of the polymers. Observing polymer surfaces by scanning electron mi- croscope, pores (diameter ; $0.5-1.5{\mu}$m) were appeared on the surface of CPB-2

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