Archives of Pharmacal Research
- Volume 15 Issue 4
- /
- Pages.356-359
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- 1992
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Antitumor Activity of Psorelea corylifolia
-
Ryu, Shi-Yong
(Korea Research Institute of Chemical Technology)
;
-
Choi, Sang-Un
(Korea Research Institute of Chemical Technology)
;
-
Lee, Chong-Ock
(Korea Research Institute of Chemical Technology)
;
- Zee, Ok-Pyo (Korea Research Institute of Chemical Technology)
- Published : 1992.12.01
Abstract
The activity-oriented fractionation of Psoralea corylifolia led to an isolation of a (+) bakuchio 1 as an activ eprinciple of its antitumoral property in vitro 1 was observed to exhibit a mild cytotoxicity against five kinds of cultured human cancer cell lines, i. e. the A549, SK-OV-3, SK-MEL-2, XF-498 and HCT15. The synthesized 2, 3-epoxide of (+)-bakuchiol 3 showed the similar activity as the (+) bakuchiol 1, whereas the other oxidation derivatives 4 and 5 including the acetyl (+) bakuchiol 2 showed a decreased activity.