대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

관동화산(款冬花散) 및 그 구성약물(構成藥物)이 기관지평활근(氣管支平滑筋)에 미치는 영향(影響)

Effects of Kwandongwhasan (款冬花散) extract and its Constituent herbs on the Contraction of Isolated Guinea Pig trachea Smooth Muscle

  • Han, Dae-Gil (Department of Oriental Medicine Graduate School of Won Kwang University)
  • 발행 : 1992.07.30
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초록

The study was carried out to investigate the effect of Kwandongwhasan extract and its constituent herbs onthe contractile force of isolated guineapig trachealis muscle and to elucidate its mechanism. The results of this study were as follows; 1. Kwandongwhasan significantly inhibited the contractile response of isolated guinea pig trachealis muscle by histamine. 2. Kwandongwhasan significantly inhibited the contractile response of isolated guinea pig trachealis muscle by acetylcholine. 3. Kwandongwhasan significantly inhibited the contractile response of isolated guinea pig trachealis muscle by 5-hydrooxytryptamine. 4. Kwandongwhasan significantly inhibited the contractile response of isolated guinea pig trachealis muscle by prostaglandin $F2\;{\alpha}$ 5. Herba Ephedrae (麻黃), Semen Armeniacae(杏仁), Cortex Mormi(紫白皮), and Flos Farfarae (款冬花), extract significantly inhibited the contractile response of isolated guinea pig trachealis muscle by histamine, acetylcholine, 5-hydroxytryptamine and prostaglandin $F2\;{\alpha}$. 6. Radix Glycyrrhdzae(甘草) extract significantly inhibited the contractile response of isolated guinea pig trachealis muscle by prostaglandia $F2\;{\alpha}$. 7. Rhizoma Anemarrhenae(知母) extract significantly inhibited the contractile response of isolated guinea pig trachealis muscle by histamine. 8. Bulbus Fritillariae(貝母) and Tuber Pinelliae(半夏) extract did not inhibit the significantly inhibited the contractile response of isolated guinea pig trachealis muscle.

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참고문헌

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