Journal of Pharmaceutical Investigation
- Volume 22 Issue 2
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- Pages.163-166
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effect of Tween 20 on the Penetration of Ketoprofen through Excised Rat Skin
트윈 20이 케토프로펜의 흰쥐 피부투과에 미치는 영향
- Kim, Jung-Ju (College of Pharmacy, Seoul National University) ;
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Chi, Sang-Cheol
(College of Pharmacy, Sung Kyun Kwan University)
;
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
-
Kim, Chong-Kook
(College of Pharmacy, Seoul National University)
- Published : 1992.06.20
Abstract
The effect of Tween 20 on the penetration of ketoprofen in aqueous vehicles through excised rat skin has been evaluated. The addition of Tween 20, up to 2%, in water containing ketoprofen decreased the penetration of ketoprofen through the skin compared with the reference vehicle without this surfactant. However, the addition of Tween 20 in ketoprofen aqueous vehicle increased diffusion parameter significantly which was compensated with the lowered partition parameter.