YAKHAK HOEJI (약학회지)
- Volume 36 Issue 6
- /
- Pages.570-576
- /
- 1992
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Protective Mechanism of Bismuth Nitrate Against Gentamicin Nephrotoxicity
질산비스마스의 겐타마이신 신독성 경감기전
- Kim, Jung-Sun (College of Pharmacy, Pusan National University) ;
- Chung, Hae-Young (College of Pharmacy, Pusan National University) ;
- Rho, Young-Jae (College of Pharmacy, Pusan National University) ;
- Lee, Sang-Rok (College of Pharmacy, Pusan National University)
- Published : 1992.12.29
Abstract
The treatment with gentamicin in the presence of pretreatment with bismuth nitrate significantly reduced blood urea nitrogen compared with given gentamicin alone. But the amelioration of gentamicin-induced nephrotoxicity by bismuth nitrate was abolished by pretreatment with indomethacin that is cyclooxygenase inhibitor, which significantly decreased renal glutathione S-transferase activity and thiobarbituric acid reactive substance compared with mice of given gentamicin and bismuth nitrate. On the other hand, treatment with bismuth nitrate significantly increased prostaglandin