약학회지 (YAKHAK HOEJI)
- 제36권4호
- /
- Pages.345-349
- /
- 1992
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
티미딜산 생성효소 활성이 높은 메토트렉세이트-내성 균주의 검색
Screening of Methotrexate-Resistant Strains with High Thymidylate Synthase Activity
- Kwak, In-Young (Department of Genetic Engineering, Pai-Chai University) ;
-
Lee, Jong-Soo
(Department of Genetic Engineering, Pai-Chai University)
- 발행 : 1992.08.29
초록
Thymidylate synthase activity from extracts of various methotrexate-resistant strains was measured by spectrophotometric assay. Methotrexate-resistant strains of Lactobacillus, Pseudomonas sp., Micrococcus sp. HS-1, Klebsillela pneumonae, Cellulomonas fimi and Serratia marcescens elevated thymidylate synthase levels, especially, Pseudomonas sp. KL-9 resistant to