YAKHAK HOEJI (약학회지)
- Volume 36 Issue 4
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- Pages.345-349
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Screening of Methotrexate-Resistant Strains with High Thymidylate Synthase Activity
티미딜산 생성효소 활성이 높은 메토트렉세이트-내성 균주의 검색
- Kwak, In-Young (Department of Genetic Engineering, Pai-Chai University) ;
- Lee, Jong-Soo (Department of Genetic Engineering, Pai-Chai University)
- Published : 1992.08.29
Abstract
Thymidylate synthase activity from extracts of various methotrexate-resistant strains was measured by spectrophotometric assay. Methotrexate-resistant strains of Lactobacillus, Pseudomonas sp., Micrococcus sp. HS-1, Klebsillela pneumonae, Cellulomonas fimi and Serratia marcescens elevated thymidylate synthase levels, especially, Pseudomonas sp. KL-9 resistant to