YAKHAK HOEJI (약학회지)
- Volume 36 Issue 4
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- Pages.334-340
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Anticlastogenic Effect of Petroleum Ether Extract of Panax ginseng Against Carcinogens-induced Micronuclei in Mice
인삼 석유에테르 추출물이 흰쥐에서 여러 발암성물질에 의해 유도된 소핵생성의 억제효과
- Choi, Sung-Gyu (Research Lab. Dong-A Pharm. Co, Ltd.) ;
- Heo, Moon-Young (College of Pharmacy, Kangweon National University)
- Published : 1992.08.29
Abstract
Ethanol, total saponin and petroleum ether extract of Panax ginseng C.A. Meyer were tested for their anticlastogenic effects against induction of micronuclei by cyclophosphamide and benzo(a)pyrene in mice. Ginseng petroleum ether extract (GPEE) showed the highest suppressive effect among three extracts. GPEE was also tested to compare their anticlastogenic effect against several well-known carcinogens: such as mitomycin C, 7, 12-dimethyl benzo(a)anthracene, ethyl methane sulfonate, dimethylnitrosamine and busulfan. GPEE showed the anticlastogenic effect against most of carcinogens, although there were no significant effects against 7, 12-dimethyl benzo(a) anthracene, dimethyl nitrosoamine and busulfan-induced micronuclei.