YAKHAK HOEJI (약학회지)
- Volume 36 Issue 4
- /
- Pages.326-333
- /
- 1992
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Synthesis and Pharmacological Activities of New Folic Acid Antagonists
새로운 엽산 대사 길항제의 합성 및 약리활성
- Sin, Kwan-Seog (College of Pharmacy, Kangweon National University) ;
- Sung, Sun-Young (College of Pharmacy, Kangweon National University) ;
- Nam, Jae-Woo (College of Pharmacy, Kangweon National University) ;
- Choi, Sang-Un (Korea Research Institute of Chemical Technology) ;
- Lee, Chong-Ock (Korea Research Institute of Chemical Technology)
- Published : 1992.08.29
Abstract
A new series of methotrexate analogues was prepared in which the
Keywords
- Folic acid antagonists;
- ${\beta}-arylmethotrexate$;
- lipophilic property;
- antibacterial actiivity;
- antitumor activity;
- Streptococcus faecium;
- murine leukemias;
- human tumor cell lines